Altogether, these results predict that Purkinje spike burst-pause dynamics are instrumental to VOR learning and reversal adaptation.Ĭitation: Luque NR, Naveros F, Carrillo RR, Ros E, Arleo A (2019) Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. Importantly, pauses are crucial to facilitate VOR phase-reversal learning, by reshaping previously learnt synaptic weight distributions. Tonic Purkinje cell firing maintains the consolidated VOR through time. In addition, properly timed and sized Purkinje cell bursts allow the ratio between long-term depression and potentiation (LTD/LTP) to be finely shaped at mossy fibre-medial vestibular nuclei synapses, which optimises VOR consolidation. This gating mechanism accounts for early and coarse VOR acquisition, prior to the late reflex consolidation. Our results suggest that pauses following Purkinje complex spikes (bursts) encode transient disinhibition of target medial vestibular nuclei, critically gating the vestibular signals conveyed by mossy fibres. A detailed Purkinje cell model reproduces the three spike-firing patterns that are shown to regulate the cerebellar output. The model captures the cerebellar microcircuit properties and it incorporates spike-based synaptic plasticity at multiple cerebellar sites. Here, a spiking cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex (VOR) adaptation. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses. The deck could flop and now you’re sitting on a bunch of trash.Cerebellar Purkinje cells mediate accurate eye movement coordination. Why risk it to make a few extra hundred?ģ is not illegal but still very speculative because it assumes the pro player’s deck will have a strong showing. If you’re an employee that collects, I would imagine you are more into vintage stuff that has small print runs or perhaps misprints. The only way insider trading (as used in the stock market) would work is:ġ: An employee knows they’re reprinting a card, so they dump their collectionĢ: Inside knowledge of a forthcoming set that will make certain existing cards more valuable/powerful, so the person would buy those cards ahead of the set releaseģ: A pro team that’s got some new tech they’re gonna use at a PT, so they preemptively buy existing stock to corner the marketġ & 2 involve an employee risking their job to make a little extra money (and 2 is still very speculative because you never know what will be good until a few big tourneys have occurred). I think he probably means speculative buying rather than organic game driven demand or overall collector demand along with low supply. No threads asking what to do with your cards or money Single questions about cards/money/selling advice should be asked in the stickied threads posted every Mo/We/Fr. "Buyer beware" posts require submitting proof with identifying info removed. SCD, Video and card photo posts must include a brief summary. No Low Effort Posts: If you are requesting research, or the answer to your question can be found through public knowledge, find it yourself and post it. No spam, flaming, brigading, harassing.Īll posts must be financially related / No counterfeit authentication requests. Friday - Things to look out for this weekend!įollow Redditiquette.Wednesday - Weekly Ask MTGFinance Anything.Monday - Weekend Wrapup! What was real and what was a trap.
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